Isaac Kohane

Kempner Faculty Steering Committee

Marion V. Nelson Professor and Chair, Department of Biomedical Informatics

Editor-in-Chief, NEJM AI

Preferred Pronouns:



Contact Information

Best way to contact me: Phone

Subjects I Teach:

  • AI and Computational medicine


Isaac “Zak” Kohane, MD, PhD, is the inaugural chair of Harvard Medical School’s Department of Biomedical Informatics, whose mission is to develop the methods, tools, and infrastructure required for a new generation of scientists and care providers to move biomedicine rapidly forward by taking advantage of the insight and precision offered by big data. He is the inaugural Editor-in-Chief of NEJM AI and co-author of a recent book, The AI Revolution in Medicine. He is a member of the National Academy of Medicine, the American Society for Clinical Investigation, and the American College of Medical Informatics.

Research Focus

Kohane’s current research focuses on AI, biomedical informatics, and endocrinology. He develops and applies computational techniques to address disease at multiple scales, from whole health care systems to the functional genomics of neurodevelopment. Kohane also has worked on AI applications in medicine since the 1990s, including automated ventilator control, pediatric growth monitoring, detection of domestic abuse, diagnosing autism from multimodal data, and most recently, assisting clinicians using whole genome sequence and clinical histories to diagnose rare or unknown disease patients.